Uruguay have been eliminated from the World Cup despite a 2-0 win over Ghana at Al Janoub Stadium in Al Wakrah, Qatar on Friday.
Ghana also failed to advance to the knockout round.
Suarez played a key role in both first-half goals for Uruguay scored by Giorgian De Arrascaeta.
Uruguay was in a position to go through until South Korea’s late goal gave it a 2-1 win over Portugal in the other Group H game. That meant Uruguay needed to score one more goal in the dying minutes of its game to qualify.
It didn’t and Suarez was distraught on the sidelines and covered his face with his shirt having been substituted in what was likely his last World Cup appearance.
The two sides famously met in the quarter-finals of the 2010 edition in a match which remains one of the most controversial games ever.
It’s almost impressive that Luis Suarez bit Giorgio Chiellini in 2014 and his antics against Ghana still remain his most controversial World Cup moment.
Former Portsmouth star Sulley Muntari had put Ghana ahead, but Diego Forlan equalised for Uruguay to send the game to extra-time.
With the match looking to be heading towards a penalty shootout, Stephen Appiah looked to have won it for Ghana in the final minute but his shot was blocked by Suarez on the line.
Dominic Adiyiah reacted quickest to head home the rebound only for Suarez to blatantly use both hands to push the ball away.
The ex-Liverpool and Barcelona striker was sent off but Asamoah Gyan smacked the crossbar from the resulting penalty.
Suarez then reaffirmed his status as a World Cup villain after cameras caught him wildly celebrating the miss while standing in the tunnel.
Uruguay went onto to win the shootout 4-2 and Ghana have not been able to replicate the heroic World Cup run since.
Otto Addo’s side finished bottom of Group G in 2014 while they missed out on qualification for 2018 altogether.